The 2025 college football season kicks off with a major Big 12 battle as No. 17 Kansas State battles No. 22 Iowa State in the annual Aer Lingus College Football Classic in Dublin, Ireland. The clash between the two historic foes -- dubbed "Farmageddon" -- ranks among the best Week 0 games in recent history and has major Big 12 championship implications.

In the wacky, wide-open world of the new Big 12 Conference, both Iowa State and Kansas State have aspirations of winning the league and earning that automatic bid to the College Football Playoff. ISU played for the conference title last year, while KSU has been a consistent presence among Big 12 contenders for many years.

Expert prediction for Kansas State vs. Iowa State in this Week 0 college football game from a model that simulates games and picks winners.