The Federal Emergency Management Agency included Camp Mystic in a "Special Flood Hazard Area" in its National Flood Insurance map for Kerr County, Texas, in 2011.

Some camps in the region had to be evacuated, and local newspapers described how Camp Mystic was among those cut off from the outside world. According to a Kerr County history book, floodwaters at Camp Mystic almost reached the top of the dining hall’s stairs.