While Cinderella teams are fun, it’s usually not wise to bet on them. The lowest seed to win March Madness was a No. 8 seed, which happened all the way back in 1985 when Villanova upset No. 1 seed Georgetown in the finals. A No. 8 seed is also the lowest seed to reach the championship game.

As one bookmaker put it, "They are running down the aisle like the Ultimate Warrior to bet March Madness." Patrick Everson reports on the early action.

Perhaps the surest sign that artificial intelligence really is taking over the world will come the day it wins your favorite March Madness bracket pool.