For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...

Unger was able to nip calcium transients in the bud by injecting a “puff” of sTREM2 into the mouse brain with a pipette; this temporarily silenced nearby neurons, and it did so in wild-type or TREM2 ...

See α-Synuclein. Candidate tracer SY08 detects α-synuclein deposits in the brainstem (right) and parietal cortex (left) of ...

Vaccine Step Down. A person’s probability of developing dementia over seven years increased with age. It was higher in the ...

A new consortium aims to speed the pace of basic science discovery in AD and related diseases. A future AI assistant is to ...

The scientists concluded that while the two markers perform similarly, they yield complementary information, and sequential ...

First author Hamilton Oh, now at Icahn School of Medicine at Mt. Sinai, New York, and colleagues identified these potential markers during a proteomics analysis of CSF from 3,397 participants in six ...

It binds both transmembrane and soluble TREM2, triggering a rise in CSF sTREM2. Single and multi-dose studies of the small ...