For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

Activation of cell death pathways typically leads to the irreversible destruction of the cell. However, in this issue of The ...

Sec1/Munc18‐like (SM) proteins functionally interact with SNARE proteins in vesicular fusion. Despite their high sequence conservation, structurally disparate binding modes for SM proteins with ...

3‐phosphoinositide dependent protein kinase‐1 (PDK1) plays a key role in regulating signalling pathways by activating AGC kinases such as PKB/Akt and S6K. Here we describe the 2.0 Å crystal structure ...

The inner membrane of the mitochondrion folds inwards, forming the cristae. This folding allows a greater amount of membrane to be packed into the mitochondrion. The data in this study demonstrate ...

References and Citations As a matter of policy, the journal requires the citation of primary literature (over review articles) and, when appropriate, of data (see section on Data citation below). The ...

image image The study demonstrates that fibroblast growth factors suppress the cellular interferon response and thereby promote viral replication. Inhibition of FGF signaling has the opposite effect, ...

Clustered regularly interspaced short palindromic repeat (CRISPR) is a recently discovered adaptive prokaryotic immune system that provides acquired immunity against foreign nucleic acids by utilizing ...

MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing pathways. Current efforts are focused on the regulatory function of miRNAs, ...

The resident prokaryotic microbiota of the metazoan gut elicits profound effects on the growth and development of the intestine. However, the molecular mechanisms of symbiotic prokaryotic–eukaryotic ...

imageimageAuxin triggers NBR1-mediated selective autophagic degradation of ARF7 to modulate periodic root branching in Arabidopsis. ARF7 is selectively degraded via NBR1-mediated autophagy Auxin ...

During bacterial cytokinesis, hydrolytic enzymes are used to split wall material shared by adjacent daughter cells to promote their separation. Precise control over these enzymes is critical to ...